Efficient Chemical Synthesis of Oligonucleotides Containing the 2-Deoxyribonolactone Site

Mitsuharu Kotera,Anne-Gaëlle Bourdat,Eric Defrancq,Muriel Jourdan,Julián García,Christian Coulombeau,Jean Lhomme

Efficient Chemical Synthesis of Oligonucleotides Containing the 2-Deoxyribonolactone Site

1999

Mitsuharu Kotera
Anne-Gaëlle Bourdat
Eric Defrancq
Muriel Jourdan
Julián García
Christian Coulombeau
Jean Lhomme

Abstract A highly efficient synthetic method for incorporation of the deoxyribonolactone lesion into oligonucleotides was developed using the photochemical properties of 7-nitroindole.

Keywords:

Chemical synthesis
Oligonucleotide
2-deoxyribonolactone
Organic chemistry
Chemistry

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