Hemodynamic Effects of Angiotensin and Renin Inhibition in Dogs with Acute Left Ventricular Failure

The effects of enalaprilat (MK-422), an angiotensin converting enzyme inhibitor, were compared to those of SCRIP, a renin inhibitor, in experimentally induced left ventricular failure. In anesthetized dogs, acute left ventricular failure was induced by repeated embolization, via the left main coronary artery, with 50 μm plastic microspheres. Embolization significantly increased left ventricular enddiastolic pressure from 6 ± 1 to 14 ± 1 (p