Multi-modal referencing platform for diffuse optical spectroscopic instruments

While many diffuse optical techniques are available to characterize the optical properties of biological tissues, a gold standard has not been proposed yet for referencing the results of these different technologies. In this context, we implemented and validated a multi-modal referencing platform for diffuse optical spectroscopic instruments, consisting of a benchtop time-resolved diffuse optical spectroscopic system, together with a spatial frequency domain imaging (SFDI) station. To validate the systems capabilities, the BitMap (“Brain Injury and Trauma Monitoring using Advanced Photonics”) European collaboration has been carried out, aiming at assessing the performances of several instruments dedicated to diffuse optical spectroscopic purposes.