Modeling of MicroRNA-Derived Disease Network Repurposes Methotrexate for the Prevention and Therapy of Abdominal Aortic Aneurysm

Highlights ● We presented a computational model to built human disease network from miRNA-disease association data; ● Applying the presented model, we built a miRNA-derived human disease network which covers 15 disease classes and includes 304 diseases; ● We revealed a number of patterns for the disease network, for example diseases tend to be clustered and coherent in the network; ● We repurposed methotrexate, a drug for autoimmune disease, to be a possible drug to prevent the formation and inhibit the development of AAA, a common serious disease without drugs in clinics.