Effects of fish scale collagen peptide on an experimental ulcerative colitis mouse model

Abstract The aim of this study was to understand the effects of fish scale collagen peptide (SC) on an experimental ulcerative colitis (UC) mouse model. SC shortened colon length, increased colon weight/length ratio, and ameliorated histological tissue injury in dextran sulfate sodium (DSS)-induced acute UC mice. SC suppressed inflammation in acute UC by decreasing myeloperoxidase-dependent activation of inflammatory cells such as leukocytes. SC suppressed the activation of nuclear factor-kappa B (NF-κB) in colon and serum monocyte chemotactic protein-1 in the DSS-induced acute UC mouse model. Gelatin, on the other hand, did not suppress clinical symptoms, colon inflammation, and colon fibrosis in DSS-induced acute UC. These results revealed that SC has anti-inflammatory effects in the DSS-induced acute UC model. Our results indicate that SC could be a new functional food for patients with inflammatory bowel disease.