Lack of Diagnostic Accuracy of the Monoclonal Stool Antigen Test for Detection of Helicobacter pylori Infection in Young Australian Aboriginal Children
2009
Background: The prevalence of Helicobacter pylori infection among
Aboriginal Australians children is unclear. The aims of the present study
are to determine the prevalence of H. pylori infection among young
Aboriginal children recovering from acute diarrheal disease in hospital and
to evaluate the H. pylori stool antigen test as a noninvasive diagnostic test
in this setting.
Methods: This was a prospective comparative study using the 13C-Urea
Breath Test as reference standard. Fifty-two children between 4 months
and 2 years of age were consecutively enrolled. These children comprised
a representative sample of Australian Aboriginal children admitted to
hospital with acute diarrheal disease from remote and rural communities
across Northern Territory of Australia.
Results: The overall prevalence of H. pylori was 44.2%. The stool antigen
test had a sensitivity of 0.55 (95% confidence interval CI: 0.35– 0.73)
with a positive predictive value of 0.65 (95% CI: 0.42–0.82). The specificity
was 0.68 (95% CI: 0.46–0.84) with a negative predictive value of 0.58 (95%
CI: 0.39–0.75). Analysis of receiver operator characteristic curve yielded an
overall accuracy of the stool antigen test of 61% (48%–75%).
Conclusions: The prevalence of H. pylori infection among very young
Aboriginal children from remote and rural communities was high and
consistent with early acquisition. The diagnostic accuracy of the stool
antigen test to diagnose H. pylori in this setting was poor.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
31
References
15
Citations
NaN
KQI