Protective effects of Evodia rutaecarpa water extract on ethanol-induced rat gastric lesions

Objective: To investigate the protective effects of Evodia rutaecarpa water extract on ethanol-induced acute gastric lesions in rats.Method: In this study,animals were intraperitoneally pretreated with vehicle(normal saline) or E.rutaecarpa at 424.8,141.6,47.2 mg·kg~(-1).Three hours later,gastric lesions were induced by topical application of 50% ethanol for 10 min.The rat gastric transmucosal potential difference(PD) was recorded continuously by ex-vivo chamber technique.NO_(x)(nitrate and nitrite) level in gastric perfusate and the length index of gastric lesions were determined in a gastric intubatton model.Result: Compared with control,Evodia rutaecarpa water extract accelerated PD recovery and reduced gastric morphologic lesions in a dose-dependent manner(P0.05),and also dose-dependently increased NO_(x) level in gastric perfusate.Especially,at 424.8 mg·kg~(-1),E.rutaecarpa promoted synthesizing of nitric oxide significantly(P0.01).Conclusion: E.rutaecarpa water extract showed effectively protective actions on ethanol-induced acute gastric lesions in rats,and the gastroprotective mechanisms maybe due to the strengthening action on gastric mucosal lining and the promotion of nitric oxide synthesis in local gastric mucosa.