Radiological characteristics of screen-detected lung cancers: predictive for histological subtype?

Methods 197 solid lung cancers (192 participants) detected in all four screening rounds of the Dutch-Belgian randomized lung cancer screening trial (NELSON) were included. CTmorphological features included nodule shape, margin, location, volume, and volume-doubling time (VDT). Based on histopathology, cancers were divided into four groups: adenocarcinoma (N=114), squamous cell carcinoma (N=37), large cell carcinoma (N=28) and neuro-endocrine cancers (N=18). Data were analyzed using ANOVA, Chi-square and Fischer’s exact test.