Elements of regulatory systems of antibiotic biosynthesis in Streptomyces

: Studies of regulation of antibiotic synthesis involved both basic and applied aspects of biology of antibiotic producers. This paper is a survey of published experimental data and key hypotheses for the regulation of antibiotic synthesis in bacteria of the genus Streptomyces. Summarized data on transcriptional regulatory systems of gene clusters responsible for biosynthesis of some antibiotics in these microorganisms are presented. Results of our previous research of the regulation of antibiotic bialaphos production in the S. hygroscopicus strain are considered as well. On the basis of these results, a hypothetical scheme of the organization of lower levels of the regulatory system of the bialaphos biosynthetic cluster was constructed. It is assumed that an integrase-like product of the brpB gene cloned by the authors mediates transcriptional initiation of this gene cluster.