Collapse Temperature of Solutions Important for Lyopreservation of Living Cells at Ambient Temperature

With recent advances in cell-based medical technologies such as tissue engineering and regenerative medicine, living cells are becoming more and more important as a therapeutic tool in modern medicine. Due to the limited availability of cell sources, effective long-term preservation of living cells is of great importance to the eventual success of these emerging technologies. Cell preservation can be achieved by cooling/freezing the cells to a cryogenic temperature (cryopreservation) and/or drying the cells to preserve at ambient temperature (lyopreservation). Due to the high cost of maintaining and inconvenience of transporting cryopreserved cells, there is an increasing demand for cell lyopreservation.Copyright © 2010 by ASME