ASSESSMENT OF THE EFFECT OF ALLIUM SATIVUM (GARLIC) AND CURCUMA LONGA (CURCUMIN) IN COMBINATION WITH DRUGS O N CULTURED TRICHOMONAS VAGINALIS

Trichomoniasis is an infectious disease caused by Trichomonas vaginalis. It inflicts severe complicationsto human genitourinary system. The devastating negative effects and resistance emergedto known medication impose the search for effective and safer alternatives. This study evaluatedthe effect of curcumin and garlic as well as combination between their effective doseswith Metronidazole® & Tinidazole®. So, vaginal swabs were obtained from the symptomaticpatients, and cultured on modified Diamond's medium. Assessment of the herbs various concentrationsat different follow-up periods was done by counting dead T. vaginalis trophozoitesby using hemocytometer and trypan blue staining. The results showed that curcumin 400mg/mlgave a promising anti-Trichomonas especially when combined with garlic 90mg/ml that showed ahigh synergistic effect.