Organtypische Slice-Kulturen aus humanen Geweben

Preclinical research is often realized with cell lines or animal models and implies difficulties regarding the translation into clinics because of limitations of the models, e. g. species differences. We have therefore established methods to cultivate human tumor tissue from resections as organotypic slice cultures. Those slices contain all cells in their natural environment including the extracellular matrix. With this model, we aim to provide a test system which is closer to the situation in patients.