РАЗРАБОТКА СПОСОБА ПОЛУЧЕНИЯ НАЛТРЕКСОНА ОСНОВАНИЯ, ИНКАПСУЛИРОВАННОГО В ПОЛИМЕРНЫЕ МИКРОЧАСТИЦЫ

The study is devoted to novel manufacturing method of preparation of polymeric microparticles, loaded by naltrexone base, in flow through regime. Special module construction was developed for providing emulsification in continuous regime. Focusing on production of polymeric microparticles with characteristics, compatible with characteristics of the pharmaceutical Vivitrol and its native analogue, parameters of encapsulation process were defined. An ability of prepared microparticles to prolonged drug release during 28 days was demonstrated.