QUANTITATIVELY MONITORING OF SOLID-PHASE ORGANIC SYNTHESIS BY COMBUSTION ELEMENTAL ANALYSIS

Abstract A systematic investigation on the role of combustion elemental analysis in the quantitative monitoring of solid-phase organic synthesis was done. Quantitative elemental analysis results obtained for eight resin-bound organic compounds are highly consistent with those obtained from well-established methods such as Fmoc method. A six-step peptoid synthesis and a dansylhydrazone synthesis were quantitatively monitored using elemental analysis. All results were corroborated by well-established photometric methods. Based on these data, the elemental analysis method is, in general, reproducible and accurate in the quantitative analysis of resin-bound organic compounds. Considering the severe shortage of on-resin quantitation methods at present, it adds a valuable tool for monitoring solid-phase organic synthesis steps that cannot be quantitated by current methods.