Study on the Epidemiological Efficacy of Vaccines Against Hemorrhagic fever with renal syndrome

Objective Observe the safety immunogenicity and epidemiological efficacy of HFRS vaccine in the focus population with high incidence of HFRS in Zhejiang province. Methods Immunofluorecent antibody assay was used in testing specific IgG antibody and Mcro-CPE method was used in testing the titer of neutralizing antibody.Results 10 460 people were vaccinated,97.30% of them completed their vaccination of full doses. 16 159 non-vaccinated people living in the same areas were used as the control group. Two weeks after the injection of the third dose,the sero-conversion rate by immunofluorecent antibody test(IgG) and neutralization test were 100%(67/67) and 44.44%,and the GMTs of them were 72.14 and 4.63 respectively. After reinforce,the rates of seroconversion of immunofluorecent antibody and neutralizing antibody were all going up,but all droped again after one year. The reaction of vaccine was little. The vaccinated group had no patient while the control group had 26 patients and 3 died. According to the six-year observation,the vaccine was effective,and his protection rate in population was 100%(95% CI :96.30%～100%). Conclusion HFRS vaccine was epidemiologically effective and safe.