Closely spaced fibre Bragg grating sensors for detailed measurement of peristalsis in the human gut
2009
We report the design and use of multi-channel fibre Bragg grating based manometry catheters with pressure sensors
spaced at 1 cm intervals along its axis. The catheters have been tested in-vivo in both the human oesophagus and colon
and have been shown to provide analogous results to commercially available solid state pressure sensors. The advantage
of using fibre gratings comes from the ability to extend the number of sensor elements without increasing the diameter or
complexity of the catheter or data acquisition system. We present our progress towards the fabrication of a manometry
catheter suitable for recording manometric data along the full length of the human colon. Results from early phase
equivalence testing and recent in-vivo trials in the human oesophagus and colon are presented. The colonic recordings
were taken in basal and post-prandial periods of 2.5 hours each. The close axial spacing of the pressure sensors has
identified the complex nature of propagating sequences in the colon in both antegrade (towards the anus) and retrograde
(away from the anus) for the first time. By sub-sampling the data using data from sensors 7 cm apart the potential to
misrepresent propagating sequences at wider sensor spacings is demonstrated and proposed as a potential reason why
correlation between peristaltic abnormalities recorded using traditional catheters, with 7.5-10 cm spaced sensors, and
actual patient symptoms remains elusive.
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