Ruthenium(III) Thiosemicarbazone Complexes: Synthesis, Characterization, DNA Binding, Antibacterial, In vitro Anticancer and Antioxidant Studies

Ruthenium(III) complexes of the type [RuBr2(PPh3)2L] (where L = monobasic bidentate thiosemicarbazone ligand) have been synthesized. Various physico-chemical and spectral techniques were used to determine the structural features of the complexes. Absorption spectroscopy was used to investigate DNA binding of the complexes. It indicated that the complexes bind to DNA through intercalation. The complexes have shown significant antibacterial activity than the ligands against a panel of bacteria. The efficiency of the complexes to arrest the growth of MCF-7 cancer cell line has been studied. This was done along with the cell viability test under in vitro conditions. Finally, antioxidative property of the complexes against DPPH radical was investigated.