SR‐Like Protein ZRANB2

ZRANB2 is an SR-like pre-mRNA splicing factor that is conserved across vertebrates. It contains two RNA-binding zinc finger domains at the N-terminus, each of which includes a tetrahedrally coordinated zinc ion which is essential for the 3D fold of the domain, and an arginine/serine-rich (RS) domain near the C-terminus. The 3D structures of each zinc finger domain have been solved by NMR spectroscopy, and a crystal structure of the second zinc finger in complex with RNA is also available. Similar zinc finger domains, known collectively as RanBP2-type zinc fingers, have been observed in other proteins and display a range of substrate-binding abilities. 3D Structure Keywords: ZRANB2; RanBP2 zinc finger; pre-mRNA splicing; RNA-binding