IN VITRO EVALUATION OF THE ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF SOME NEW N-(2-DIALKYLAMINOETHYL)BENZANILIDES

The use of most antimicrobial agents is presently limited worldwide, not only by the rapidly developing drug resistance, but also by the unsatisfactory status of present treatment of bacterial and fungal infections and drug side effects. Therefore the development of new and different antimicrobial drugs is an important objective and many research studies are directed towards the design of new agents. Recently substituted anilides have received considerable attention because some of them are generally considered good bacterostatic and fungistatic substances. The present study is a follow-up paper to the previous articles dealing with the biologically active amides as potential antimicrobial drugs. In our laboratory we obtained new N-(2-dialkylaminoethyl)benzanilides which were tested to determinate the minimal inhibitory concentration (MIC) in order to evaluate their in vitro antimicrobial and antifungal activity. The importance of substituents in the benzoyl ring and in the anilide moiety for optimal activity have been noted. Rezumat Utilizarea medicamentelor antimicrobiene este limitată, din cauza dezvoltării rapide a rezistenţei la medicamentele respective, a profilului nesatisfăcător al actualului arsenal terapeutic utilizat pentru tratarea infecţiilor microbiene si fungice si efectelor adverse ale acestor medicamente. De aceea dezvoltarea de noi medicamente antimicrobiene reprezintă un obiectiv important, foarte multe proiecte de cercetare având drept scop proiectarea de noi substanţe. Anilidele divers substituite au revenit recent in atenţie deoarece mai mulţi reprezentanţi sunt consideraţi substanţe cu un bun potenţial bacteriostatic si fungistatic. Acest studiu continuă studiile in care s-au cercetat amidele cu acţiune biocidă ca potenţiale medicamente antimicrobiene. Am obţinut in laborator noi N(dialchilaminoetil)benzanilide care au fost testate in vederea determinării concentraţiei minime inhibitorii (CMI) pentru a evalua activitatea antimicrobiană si antifungică in vitro a acestora. Am observat importanţa substituenţilor pe structura benzanilidică pentru apariţia unui efect biologic optim.