Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV.

Nisreen M.A. Okba,Ivy Widjaja,Brenda van Dieren,Andrea Aebischer,Geert van Amerongen,Leon de Waal,Koert J. Stittelaar,Debby Schipper,Byron E. E. Martina,Judith M. A. van den Brand,Martin Beer,Berend Jan Bosch,Bart L. Haagmans

Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV.

2020

Nisreen M.A. Okba
Ivy Widjaja
Brenda van Dieren
Andrea Aebischer
Geert van Amerongen
Leon de Waal
Koert J. Stittelaar
Debby Schipper
Byron E. E. Martina
Judith M. A. van den Brand
Martin Beer
Berend Jan Bosch
Bart L. Haagmans

Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for which vaccines are urgently needed. Using an immune-focusing approach, we created self-assembling particles mu...

Keywords:

Coronavirus disease 2019
Pathogen
severe acute respiratory syndrome coronavirus 2
Immune system
Virology
2019 20 coronavirus outbreak
Ligand (biochemistry)
Lumazine synthase
Middle East respiratory syndrome coronavirus
Biology
Viral replication
Heptad repeat
Immunogenicity
Vaccination
Antigen presentation
Avidity
Chemistry

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