Varieties and Mechanisms of Synergistic Factors Enhancing Baculovirus Infectivity

: Baculoviruses are a diverse group of viruses with double-stranded circular DNA genomes. They have certain advantageous properties for biotechnology applications, including high host specificity and environmental friendliness.Baculoviruses could play more important roles in sustainable agriculture as potential microbial insecticides. However, the popularization and application of baculovirus-based insecticides were seriously restricted due to deficiencies such as low virulence and slow rates of action. The infectivity of baculoviruses can be improved by synergistic factors. The present review summarizes characteristics of seven types of synergistic factors including baculovirus enhancin, entomopoxvirus fusolin and calcofluor. The mechanisms of these seven synergistic factors were analyzed. The information presented in this review can serve as a reference to aid in the development and application of baculovirus-based insecticides.