The value of urine Soluble Triggering Receptor expressed on Myloid cell-1 in early diagnosis of Sepsis associated Acute Kidney Injury

IntroductionWe explored the diagnostic value of a urine soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for early sepsis identification, severity and prognosis assessment, and for secondary acute kidney injury (AKI). We compared this with white blood cell (WBC) counts, serum C-reactive protein (CRP), urine output, creatinine clearance (CCr), serum creatinine (SCr), and blood urea nitrogen (BUN).MethodsThis case control study will be conducted on 50 critically ill children with sepsis admitted to PICU and 20 healthy children as control group.Study group will be classified as follows :I. Patients : - group (A) : Septic patients with AKI- group (B) : Septic patients without AKIII. Control group (20) with the same age&sexResults for urine Strem-1,CBC,CRB and S.Creatinine were recorded on day 1ResultsThere were no significant differences between all groups as regard age & gender. P values were 0.43 & 0.709 respectivelysTREM-1 showed overall significant difference between all groups (P value