The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons

Simone Denise Salamoni,Jaderson Costa da Costa,Mario Sergio Palma,Katsuhiro Konno,Ken-ichi Nihei,Ney Azambuja,Eliseu Paglioli Neto,Gianina Teribele Venturin,Andrea Luisa Alencar Tavares,Daniela Souza de Abreu,Ricardo Vaz Breda

The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons

2005

Simone Denise Salamoni
Jaderson Costa da Costa
Mario Sergio Palma
Katsuhiro Konno
Ken-ichi Nihei
Ney Azambuja
Eliseu Paglioli Neto
Gianina Teribele Venturin
Andrea Luisa Alencar Tavares
Daniela Souza de Abreu
Ricardo Vaz Breda

We analyzed the effect of the acylpolyaminetoxin JSTX-3 on the epileptogenic discharges induced by perfusion of human hippocampal slices with artificial cerebrospinal fluid lacking Mg2+ or N-methyl-D-aspartate. Hippocampi were surgically removed from patients with refractory medial temporal lobe epi

Keywords:

Temporal lobe
Endocrinology
Hippocampus (mythology)
Internal medicine
Hippocampus
Central nervous system
Hippocampal formation
Glutamate receptor
NMDA receptor
Biology
Neuron
N methyl D aspartate receptors

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