ŞİZOFRENİ HASTALARINDA GÖZÜN ARKA SEGMENT YAPILARININ DEĞERLENDİRİLMESİ Evaluation of Posterior Ocular Structures in Patients with Schizophrenia
2019
OZET Amac: Bu calismada, sizofreni hastaliginin gozun arka segment yapilarindan retina sinir lifi tabakasi (RSLT), santral makular kalinlik (SMK), koroidal kalinlik (KK) ve lamina kribroza (LK) olcumleri uzerine etkisinin degerlendirilmesi amaclanmistir. Gerec ve Yontemler: Calismaya sizofrenisi bulunan 35 hasta ve 35 saglikli katilimci dahil edilmistir. Her hastanin yalnizca sag gozu calisilmistir. Fourier domain optik koherens tomografi (OKT) ile her kadrandan RSLT kalinligi, KK, SMK, LK kalinligi ve LK derinligi (LKD) olcumleri yapilmistir ve her deger gruplar arasinda karsilastirilmistir. Bulgular: Gruplar arasinda ortalama yas ve cinsiyet dagilimlari benzerdi (p=0.528 ve p=0.299). Ortalama, superior, inferior, nazal ve temporal RSLT kalinliklari sizofrenisi bulunan hastalarda, kontrollere gore anlamli olarak dusuktu (sirasiyla; p<0.001, p<0.001, p=0.001, p=0.002 ve p<0.001). Fovea alti ve cevresindeki ortalama KK olcumleri gruplar arasinda anlamli farklilik gostermiyordu (fovea alti; p=0.676, 1.5 mm nazal; p=0.632, 3 mm nazal; p=1.000, 1.5 mm temporal; p=0.811, 3 mm temporal; p=0.145). Ortalama SMK gruplar arasinda benzerdi (p=0.678). LK kalinligi ve LKD, gruplar arasinda istatistiksel acidan anlamli farklilik gostermiyordu (p=0.816 ve p=0.161). Sonuclar: Tum kadranlardaki RSLT kalinliklari sizofreni hastalarinda kontrol grubuna gore anlamli sekilde dusuktu. Fakat SMK, fovea alti ve cevresi KK, LK kalinligi ve LKD olcumlerinde gruplar arasinda anlamli fark yoktu. Bu bulgular sizofreni hastalarinda noron kayiplarinin goruntulenmesinde, RSLT kalinliginin degerlendirildigi OKT’nin kullanilabilecegini gosterdi. Anahtar kelimeler: Şizofreni; Retina sinir lifi tabakasi; Koroidal kalinlik; Lamina kribroza kalinligi; Makular kalinlik ABSTRACT Purpose: We aimed to evaluate the effects of schizophrenia on posterior ocular structures including the retinal nerve fiber layer (RNFL), central macular thickness (CMT), choroidal thickness (CT) and lamina cribrosa (LC) measurements. Methods: A total of 35 patients with schizophrenia and 35 healthy individuals were enrolled. Only the right eye of each participant was tested. RNFL thickness in all quadrants, CT, CMT, LC thickness, and LC depth (LCD) measurements were performed using Fourier domain optic coherence tomography (OCT), and each variable was compared between groups. Results: The mean age and sex distributions were similar between groups (p=0.528 and p=0.299, respectively). The average, superior, inferior, nasal, and temporal RNFL thicknesses were significantly lower in schizophrenia patients than in controls (p<0.001, p<0.001, p=0.001, p=0.002 and p<0.001, respectively). The mean subfoveal and perifoveal CT were not significantly different between the groups (subfoveal; p=0.676, 1.5 mm nasal; p=0.632, 3 mm nasal; p=1.000, 1.5 mm temporal; p=0.811, 3 mm temporal; p=0.145). The mean CMT was similar among the groups (p=0.678). LC thickness and LCD were not statistically significant between groups (p=0.816 and p=0.161). Conclusions: We demonstrated that RNFL thicknesses in all quadrants were significantly lower in schizophrenia patients than in control subjects. However, there were no significant differences in the CMT, perifoveal and subfoveal CT, LC thickness, and LCD between the groups. These results suggest that OCT can be used to image neuronal loss by evaluating the RNFL in patients with schizophrenia. Keywords: Schizophrenia; Retinal nerve fiber layer; Choroidal thickness; Lamina cribrosa thickness; Macular thickness
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