The DTI changes and peripheral blood test results corroborate the early brain damage of SIV-infected rhesus

Abstract Object In China, there are 789617 patients infected by HIV/AIDS until March 2018. DTI is sensitive to the integrity of tissue microstructure. The changes in SIV-mac239 infected rhesus monkey’s structure and brain function are very similar to humans. This study is designed to study the relationship of DTI parameters(FA, AD) values and the peripheral blood examination results at the time before infection, 12 weeks after infection and 24 weeks after infection. Method Four healthy adult male rhesus monkeys(aged 3-5 years, weighted 5.0-7.0 kg) were involved. Linear regression analysis was applied to analyze the correlation between DTI parameters(FA, AD) and the peripheral blood examination results. Results The results showed as the FA value decreased, the mean reticulocyte volume(MRV) increased, the mean corpuscular hemoglobin concentration(MCHC) increased, the total protein(TP) increased, the immature lymphocytes(IML%) increased, the plasma prothrombin time(PT) increased and globulin levels(GLOB) increased. As the AD values increased, reticulocyte count(RET%) increased, hematocrit(HCT) increased, CD3+ lymphocyte counts elevated, lymphocyte percentage(LYM%) significantly decreased; platelet volume(PCT) increased; glucose(Glu) decreased, blood urea(UN) decreased, and blood chloride(Cl) decreased. Conclusion This study found that the FD, AD values of temporal lobe brain were associated with the peripheral blood test results, implying the mutual corroboration of the brain damage.