Local hyperestradiolemia of the uterus in the pathogenesis of hyperplastic endometrial processes

: The study of local blood flow in the uterus in 100 cases of uterine fibromyoma established increased blood levels of estradiol and progesteron. Blood estradiol level in the local flow of the uterus was relatively high in postmenopausal women, particularly, in those suffering uterine myoma. "Foreign" estradiol-dependent tissue substrates such as myoma and hyperplastic lesions of the endometrium were found to be responsible for potentiating local transfer and thus raising local concentration of ovarian hormones. Regulation of subovarian transfer and accumulation of hormones was shown to be to a large extent independent of levels of basic sex steroids in the general blood flow of the female body. Chronic local hyperestradiolemia in the uterus is the key factor for hyperplastic lesions development in the endometrium.