New analogues of agmatine with higher affinity to imidazoline receptors

Abstract Compilation of agmatine structure and imidazoline ring leads to a new family of imidazoline/α 2 -adrenoceptor ligands, 4(5)-(2-aminoethyl)imidazoline derivatives. Constraining of the guanidine moiety into heterocyclic ring improved the affinities of the resultant fusion compounds in comparison to agmatine itself. In this work, the synthetic approach and results for I 1 , I 2 , and α 2 -adrenoceptors affinities are reported.