Nanoparticulate detection systems for the evaluation of New Drug Delivery Approaches and Drug Targeting principles

In order to provide nanoparticulate detection systems for the evaluation of drug delivery approaches, two complementary particle types were optimized with respect to their physical and chemical properties. Hydrophilic coated quantum dots and colloidal gold nanoparticles were established as platforms for the investigation of drug targeting and nanoparticle diffusion. By optimizing the synthesis towards longer emission wavelengths the quantum dots will become suitable for near IR in vivo imaging and the synthesized coating polymers for the gold particles furthermore provided an excellent in vitro stability, which was demonstrated in an in-vivo experiment. Both systems proved to be valuable partners for the design of new drug delivery formulations.