Gezieltes Entwickeln und Optimieren von Kapselformulierungen mit einer instrumentierten Dosierröhrchen-Kapselfüllmaschine. II: Grundlagen der Optimierungsstrategie
1993
On an instrumented capsule filling machine (Zanasi LZ 64) with intermittent operation, the influence of the excipient- and machine parameters on the filling of the capsules and the dissolution rate using coffeine as model substance was determined. It was found that a sufficient lubrication of the capsule mixture, measurable by low ejection forces, is critical for a uniform fill weight: Adding too much lubrificant, however, prevents the compact from forming and the standard deviation of the fill weight increases. Magnesium stearate and Precirol are more effective lubricants than stearic dispersion
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