Controlling Coagulation in Blood with Red Light.
2021
Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalysed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood - restoring the blood's natural coagulation capability.
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