Palladium-catalyzed domino Heck-disilylation and Heck-monosilylation of alkene-tethered carbamoyl chlorides: synthesis of versatile silylated oxindoles
2021
We report efficient palladium-catalyzed domino Heck-silylation of alkene-tethered carbamoyl chlorides with hexamethyldisilane. By using this protocol, a variety of mono- and disilylated oxindoles were obtained in moderate to good yields. Notably, this research provides the first palladium-catalyzed methodology to synthesize diverse disilylated oxindoles at room temperature which is superior to previous methods.
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