Symmetrical Drug-related Intertriginous and Flexural Exanthema (SDRIFE)

Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a symmetrical erythematous rash on the gluteal and intertriginous areas observed after exposure to systemic drugs.[1] Previously, in 1984, it was referred as baboon syndrome, due to the distribution of the lesions which localized to the buttocks and inner thighs (resembling the red rump of baboons), and observed as a response to systemic or local administration of contact allergens and drugs.[2] Hausermann proposed the term SDRIFE in 2004 as more appropriate for those reactions occurring after exposure to systemic drugs, regardless of prior sensitization.[3] SDRIFE is distinct from other cutaneous drug reactions due to its typical morphology, distribution, and the absence of systemic findings.