NFIL-trating the Host Circadian Rhythm—Microbes Fine-Tune the Epithelial Clock

The diurnal activities of the intestinal microbiota and its host are closely connected, but the nature of their circadian communication pathways remains obscure. Wang et al. (2017) have described a signaling circuit linking microbial sensing by the immune system to the epithelial clock, thereby orchestrating local and systemic lipid metabolism.