ABCL-321: Clinicopathological Profile of Gastrointestinal Lymphoma Diagnosed Over a Period of 6-Years: A Tertiary Care Center Experience

Context GI lymphomas (GIL) comprise approximately 1%–10% of all malignancies that arise in the gastrointestinal tract (GIT). GILs show heterogeneity in terms of distribution patterns, histopathological subtypes, disease manifestations, and treatment offered. Objective To determine the clinicopathological profile of lymphomas in the GIT. Design This is a retrospective study. All GIL-related data were retrieved from a database maintained by the Department of Pathology, All India Institute of Medical Sciences, New Delhi. The cases with incomplete diagnoses were reviewed, and an appropriate immunohistochemistry (IHC) panel was performed, followed by reclassification according to the 2017 WHO classification. Setting This is a hospital-based study from a tertiary care hospital and referral center with maximal investment by the central government. The biopsy, hematology, and radiology workup were done as a part of patient management and came at a minimal cost. The costs of histopathological diagnosis and routine blood counts, X-rays, and biochemistry are free. Patients or Other Participants Demographic details of all the cases were retrieved from the database. We have selected only those cases that had adequate diagnostic tissue and had an incomplete diagnosis for review. Results A total of 391(8.21%) cases of GIL were identified out of 4,758 total cases of lymphomas diagnosed over a period of 6 years, from 2015 to 2020. Out of these 391 cases of GILs, 364 were primary GILs, and 27 cases were secondarily involved GIL. Males are predominantly affected (M:F=3:1). The mean age is 40.6 yrs, with a range from 2 to 88 yrs. In the GIT, the stomach is the most common site of involvement (50%), followed by small intestine (28%) and large intestine (21.25%). DLBCL-NOS is the most common GIL (56.25%), followed by MALToma (15.35%), Burkitt lymphoma (10.5%), high-grade B-cell lymphoma-NOS (6.14%), T-cell NHL (3.84%), and other rare lymphomas, including IPSID, mantle cell lymphomas, duodenal type follicular lymphoma, and plasmablastic lymphomas. Conclusions It will be the largest single-institution study from India regarding gastrointestinal distribution and various subtypes of GILs. The stomach is the most common site of involvement for GILs, and DLBCL-NOS is the most common subtype of lymphoma involving the GIT, which is similar to studies published in western literature. Grant acknowledgments SERB ECR/2015/452, EEQ/2016/402, AIIMS-A_653