Non-alkaloid constituents of Vinca major.

Abstract The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl (DPPH)-scavenging activity of Compounds 1 – 7 were evaluated. One new iridoid glycoside (compound 1 ), together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5 , and 6 showed moderate DPPH-scavenging activity, with IC 50 values being 70.6, 32.8, and 62.2 μmol·L −1 , respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.