Approach to the A-B Ring System of Forskolin through Biotransformation of Toluene

In the present work, we will intend to show that diol I, microbially derived from toluene using Pseudomonas putida 39D, is a suitable synthon for the synthesis of the A-B ring system of forskolin. The functionalization of diol I, to be used as ring-B, and the attempts of ring-A closure, will be disclosed.