Correlations Expression PTEN and Expression IGFR with Expression Ki-67 and The Grading Histopathology of Carcinoma Mammae Invasive

Carcinoma of mammae is a basis of the greatest ferocity that was discovered in of women in the project in an advanced state of and developing countries. Many a gene that has reportedly exchanged in carcinogenesis carcinoma mammae as PTEN, IGFR, Ki-67, Her-2 neu, and p53 are classified as a factor prognostic. It is still a little research report about the expression of PTEN and expression IGFR in the case carcinoma mammae invasive especially in Indonesia. The purpose of this study is to know the relationship between expression PTEN and expression IGFR with Ki-67 expression and grade histopatology of carcinoma mammae invasive. This study took data from Center Diagnostic Anatomical Pathology Department of Medical Faculty, Andalas University, West Sumatera, Indonesia, the period of 1 January 2014 to 31 December 2015. The expression of by immunohistochemistry (IHC) PTEN, IGFR and Ki-67 antibodies in paraffin block from 55 cases of carcinoma mammae invasive diagnosed. PTEN and IGFR positive expression were mostly found in grade II carcinoma mammae invasive compared to grade III. Expression Ki-67 ≥ 14 % more found on the expression of PTEN and IGFR positive. There was no significant correlation between PTEN expression with grading histopathology and expression of Ki-67; the same there was no significant correlation between IGFR expression with grading histopathology and expression of Ki-67