Epigenetic and Genetic Alterations in Leukemia

Understanding of the genetic and epigenetic factors contributing to the pathogenesis of leukemia has a high impact on blood cancer therapy. In Chap. 1 we review the hematopoiesis process—formation of blood cells from fetus development throughout adulthood. The number of genetic and epigenetic alterations that arise in normal cells during the many years of life could cause blood cancer. The types of leukemia, pathogenesis of AML, and genetic and epigenetic landscape of AML are presented in the chapter. Also standard and new strategies of AML treatment to improve remission induction are described.