N- benzyl-4-methyl-3-piperidine-one

The present invention discloses a method for synthesizing N- benzyl-4-methyl-3-piperidone to 3-hydroxy-4-methylpyridine and benzyl chloride as a starting material, comprising the following steps: 1) 3-hydroxy-4-methylpyridine was added to the reaction solvent I, benzyl chloride and the reaction mixture was added dropwise at room temperature and the solvent I was heated to reflux; 2) adding an aqueous alkaline solution in step 1) the resulting 3-hydroxy 4-methylpyridine benzyl chloride and the reducing agent, and then warmed to reflux; 3) step 2) the obtained N- benzyl-3-hydroxy-4-methylpiperidine was added to the reaction solvent II dropwise was added a solution of CrO 3 and concentrated sulfuric acid, at room temperature to obtain N- benzyl-4-methyl-3-piperidone. This synthetic method has a total yield characteristics.