Clinical significance of combined detection of Survivin and MUC7 in urine in the detection of bladder cancer

Objective To investigate the clinical value of detection of Survivin and mucin 7 (MUC7) in urine in the diagnosis of bladder cancer. Methods Seventy-five patients with bladder cancer, 38 patients with benign diseases of urinary system and 20 healthy volunteers were enrolled, and three urine specimens were collected in all patients. The clinical value of three methods in the diagnosis of bladder cancer was analyzed and compared by detecting the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of Survivin, MUC7 and cytology in urine respectively. Results The sensitivity and specificity of Survivin in the diagnosis of bladder cancer were 93.3% and 98.3%, respectively. The sensitivity and specificity of MUC7 in the diagnosis of bladder cancer were 80% and 100%, respectively. The sensitivity and specificity of cytology in the diagnosis of bladder cancer were 66.7% and 100%, respectively. The sensitivity and specificity of Survivin combined with MUC7 were 98.7% and 100%, respectively. The significant differences were observed in the sensitivity when comparing Survivin or MUC7 with the cytology respectively (P<0.05). The accuracy of Survivin combined with MUC7, Survivin MUC7 and cytology were 99.2%, 95.5%, 88.7% and 81.2.3%, respectively, which had obviously increasement compared with cytology group (78.3%) (P<0.05, respectively). Conclusions Combination of Survivin and MUC7 can improve the sensitivity and accuracy in diagnosis of bladder cancer. Key words: Bladder cancer; Survivin; Mucin 7; Urine; Tumor markers