Synthesis of γ-lactam lignans via aza-michael addition

Matthieu Dorbec,Jean-Claude Florent,Claude Monneret,Marie-Noëlle Rager,Emmanuel Bertounesque

Synthesis of γ-lactam lignans via aza-michael addition

2006

Matthieu Dorbec
Jean-Claude Florent
Claude Monneret
Marie-Noëlle Rager
Emmanuel Bertounesque

The synthesis of γ-lactam lignans from thuriferic acid via Michael addition of substituted anilines under basic conditions, followed by lactam ring closure, is described.

Keywords:

Lactam
Organic chemistry
Stereochemistry
Chemistry
Thuriferic acid
Michael reaction
Combinatorial chemistry

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