Evaluation of the effectiveness of corinfar in patients with ischemic heart disease using a method of repeated transesophageal electric stimulation of the left atrium

The efficiency of 20 mg corinfar, administered sublingually, was assessed by means of esophageal left-atrial electrostimulation (EES) in 49 coronary patients with angina of functional classes 1 through 4. The antiischemic effect of corinfar was evaluated within 30 min after the administration in 27 patients and within 1 hour after the administration in 22 patients. To assess the reproducibility of the results, repeated EES was performed in 11 patients, treated with placebo this time. Corinfar was shown to have a good antiischemic effect 1 hour after sublingual administration, with the maximum induced heart rate rising from 130 to 147 beats per minute and the total duration of the stimulation increasing from 232 to 308 seconds. It is demonstrated that paired EES may be used for the assessment of corinfar efficiency in coronary patients.