Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors
2007
Abstract From chemical compound library screening using an HCV NS5B RNA-dependent RNA polymerase enzymatic assay, we identified a substituted quinoxaline hit with an IC 50 of 5.5 μM. A series of substituted quinoxaline amide derivatives were synthesized based on the hit’s pharmacophore, and a good structure–activity relationship was observed. Computer modeling analysis was employed to help comprehend the SAR.
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