Biodistribution and preclinical radioimmunotherapy studies using radiolanthanide‐labeled immunoconjugates

Lutetium-177 ( 177 Lu), samarium-153 ( 153 Sm), and yttrium-90 ( 90 Y) are members of the family of elements known as lanthanides or rare earths. Monoclonal antibody CC49, a murine immunoglobulin (Ig) G1, which is reactive with the tumor-associated antigen TAG-72, previously has been shown to react with a wide range of human carcinomas. The authors review here the comparative biodistributions of CC49 IgG and F(ab') 2 fragments labeled with 177 Lu, 153 Sm, and 90 Y using the bifunctional chelating agent PA-DOTA