Early drop-out: An indication of treatment success or difficulties?

s / Drug and Alcohol Dependence 140 (2014) e2–e85 e5 Results: High impulsive rats exhibit a higher 5-HT2AR0:5HT2CR protein ratio in synaptosomes frommPFC vs. low impulsive rats (p<0.05). Rats with a knockdown of 5-HT2CR in the mPFC expressed significantly elevated impulsive action relative to control rats (p<0.05) and enhancedpotency of the 5-HT2AR antagonist M100907 to suppress impulsive action (p<0.05). In rats trained to SA cocaine (0.75mg/kg/inf; FR5; 14 days) and then assessed for cue reactivity on FADay 1 or FADay 30, we observed elevated cue reactivity and a late-forming increase in the 5-HT2AR:5-HT2CR mPFC synaptosomal protein ratio at FA Day 30 (p<0.05). Conclusions: These data indicate that there is a reciprocal or interactive relationship between 5-HT2AR and 5-HT2CR, notably in mPFC, that is key in expression of these phenotypes, and that a 5-HT2AR:5-HT2CR imbalance may be a functionally-relevant mechanism underlying impulsivity and cue reactivity. Financial support: DA06511, DA024157, DA000403. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.034 Novel association of amgydala prodynorphin with addiction and negative affect-related neurocircuitry Sarah Ann R. Anderson1, M. Michaelides1, J. Neumaier2, M. Bannon3, Yasmin L. Hurd1 1 Pharmacology, MSSM, New York, NY, United States 2 Psychiatry, University of Washington, Seattle, WA, United States 3 Pharmacology, Wayne State University, Detroit, MI,