A method of preparing clarithromycin

The present invention provides a method of (2 ', 4 "-O- bis (trimethylsilyl)) - erythromycin A-9 [O- (1- ethoxy-1-methylethyl)] oxime compound the new method of preparing clarithromycin, comprises two steps: a, methylation reaction; B, the next step of the methylation was deprotected at a certain temperature, the reaction oxime advantages are: the use of methylation reactions. methyl bromide, the reaction temperature is low, methyl better selectivity, simple post-treatment, "waste" less, significant cost reductions and more suitable for industrial production. deprotection with acetic acid, weak acid, less by-products.