Cell surface characteristics of human histiocytic lymphoma cell lines. II. Expression of Helix pomatia a hemagglutinin binding surface glycoproteins, HLA-DR and common acute lymphocytic leukemia (cALL) antigen

Abstract A panel of human cell lines, derived from diffuse histiocytic lymphoma (HL), have been analyzed for the expression of Helix pomatia A hemagglutinin (HP) binding surface glycoproteins, HLA-DR and common acute lymphoblastic leukemia (cALL) antigen. The expression of HP receptors and HLA-DR was compared to that of other normal and malignant lymphoid and non-lymphoid cell lines. It is concluded that tumors of the histopathological entity HL, according to Rappaport's [31] classification, are heterogenous in their expression of HP receptors, HLA-DR and cALL. Taken together with other features the present findings suggest that at least three types of HL exist, origin from (a) monocytic cells (extremely rare) (b) B-lymphocytes (most common) (c) non-T, non-B lymphocytes (relatively rare).