Transvaginal photoacoustic imaging probe and system based on a multiport fiber-optic beamsplitter and a real time imager for ovarian cancer detection
2013
This paper presents a real-time transvaginal photoacoustic imaging probe for imaging human ovaries in vivo. The probe
consists of a high-throughput (up to 80%) fiber-optic 1 x 19 beamsplitters, a commercial array ultrasound transducer,
and a fiber protective sheath. The beamsplitter has a 940-micron core diameter input fiber and 240-micron core diameter
output fibers numbering 36. The 36 small-core output fibers surround the ultrasound transducer and delivers light to the
tissue during imaging. A protective sheath, modeled in the form of the transducer using a 3-D printer, encloses the
transducer with array of fibers. A real-time image acquisition system collects and processes the photoacoustic RF signals
from the transducer, and displays the images formed on a monitor in real time. Additionally, the system is capable of
coregistered pulse-echo ultrasound imaging. In this way, we obtain both morphological and functional information from
the ovarian tissue. Photoacousitc images of malignant human ovaries taken ex vivo with the probe revealed blood
vascular and networks that was distinguishable from normal ovaries, making the probe potential useful for characterizing
ovarian tissue.
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