Antibodies to m-csf

The present invention relates to antibodies and antigen bind portions thereof that specifically binds to (accumulation factor macrophage colony) M-CSF, preferably human M-CSF, and operates to inhibit M-CSF. anti-M-CSF human antibodies and portions which bind antigen thereof. Antibodies are chimeric, bispecific, derivatized, single antibodies or portions of fusion proteins chain. isolated immunoglobulin heavy and light chain-derived anti-M-CSF human antibodies and nucleic acid molecules encoding such immunoglobulins that. Methods for making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. Methods of gene therapy using nucleic acid molecules encoding the heavy and / or light chain immunoglobulin molecules comprising human anti-MCSF antibody. transgenic animals and transgenic plants comprising nucleic acid molecules of the present. CLAIMS 1. A human monoclonal antibody or a portion thereof league antigen, characterized in that specifically binds to M-CSF. Claim 16: The use according to claim 15, wherein the condition is rheumatoid arthritis. Claim 17: Use of an antibody or antigen link portion according to any of claims 1-13, wherein the use is the preparation of a medicament for the treatment of a solid tumor such as a sarcoma, a carcinoma, or a non-solid tumor such as a lymphoma, in a subject, including a human. Claim 19: An isolated cell line that produces the antibody characterized or portion thereof antigen link according to any of claims 1-13 or the heavy chain or light chain of said antibody or said portions linking antigen.