Применение лечебной гипотермии при лечении тяжелой интранатальной асфиксии

The article presents results of a retrospective open-controlled clinical research with a resolution of the Ethics Committee performed in 23 neonates born in asphyxia and treated at the NICU. All newborns due to the presence of indications, overall controlled hypothermia was conducted according to the approved protocol, using the apparatus “Allon 2001”. Severe hypoxic-ischemic encephalopathy newborn develops more frequently (p=0,005) in nulliparous. There were no deaths in the studying group. Serious central nervous system damage developed in 4 (17,39 %) children in the outcome of the disease. Convulsions within 1 day of life were observed in 16 (69,56 %) newborns. The connection of the lowest values of the BE and blood pH at birth with a change in the hemostatic system in the direction of anticoagulation is identified. The correlation of the most severe complications of asphyxia of second birth stage is determined statistically, as well as EEG signs of severe depression of brain function. Predictor of the severity of clinical outcomes of hypoxic-ischemic encephalopathy to the end of 1 month of life is the presence of seizures during the first hours of life (p = 0,03), as well as primary inhibition activity and EEG flattening per 1—2 days of life (p = 0,04 ).